When I play WOW as a druid, I use all of those buttons AND they have shift and control binds.
Control 1-6 on it are for shifting forms.
1 and shift 1 are two different kinds of charge (one interrupts) and they’re onmouseover macros. Also one of those spells is actually 4 different spells depending on form.
2 and shift 2 are my main heal and decurse
3 and shift 3 are ranged damage dot and root
4 and shift 4 are stun and aoe stun
5 is something generic I rarely cast because shift-5 since it’s mapped to numpad isn’t a key
6 and shift 6 are defensive cooldowns
7 and shift 7 are another type of stun/gouge
not remembering some of the next ones
10 and shift-10 are “interface actions” where you’re doing a quest or in a zone with a special action
11 shift 11 and 12 and shift 12 are consumables/potions, gliders? But not the combat potion, that’s G.
None of those are my main line actions where I only use my left hand and for the most part just 1-6 and shift 1-6, and everything is keyed/macro’d out depending on spec and talents.
Some other keys around wasd have some kind of uses as well… trinkets… things that I don’t need to aim or target and need to hand-hold.
Edit: Oh and I have a foot-pedal for coms. Used to use five footpedals when the game was more complicated.